A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient (guest star John Scurti) who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

Cast: Hugh Laurie, Omar Epps, Robert Sean Leonard, Jesse Spencer, Peter Jacobson, Odette Annable, Charlyne Yi, Mark Atteberry, Henry Clarke, Jennifer Crystal Foley, Jim Gleason, Zena Grey, Jack N. Harding, Dava Krause, Elizabeth Lackey