An Alzheimer's patient visits Princeton Plainsboro as part of a hospital sanctioned drug trial, but when he inexplicably suffers from violent vomiting and an increasingly explosive temper, the team begins to unravel a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, House and Foreman butt heads, and Wilson treats a patient who claims to be in a chaste marriage.

Cast: Hugh Laurie, Omar Epps, Robert Sean Leonard, Jesse Spencer, Peter Jacobson, Odette Annable, Charlyne Yi, Melanie Lynskey, Angel Oquendo, Ryan Alosio, Bobbin Bergstrom, Roma Chugani, Mario Cortez, Corri English, Ian Gregory