The team takes on the case of Dr. Peter Treiber, a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.

Cast: Hugh Laurie, Omar Epps, Robert Sean Leonard, Jesse Spencer, Peter Jacobson, Odette Annable, Charlyne Yi, Jamie Elman