When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth, who happens to be doctor herself, specializing in her daughter's condition. The team must also deal with the battles raging between Emily's mother and father who have conflicting views on how to handle her health issues. When searching the family's home for clues to Emily's illness, the team realizes that Elizabeth's determination to cure her daughter could be the very thing that is killing her. Meanwhile, House and Wilson take a little vacation.

Cast: Hugh Laurie, Omar Epps, Robert Sean Leonard, Jesse Spencer, Peter Jacobson, Odette Annable, Charlyne Yi, Bobbin Bergstrom, Art Chudabala, Jessica Collins, Rachel Eggleston, Chris McKenna, Patrick Price, Gabriel Suttle