A typical family has their lives turned upside down after a plane crash leaves them with super powers. Jim, the father, tries to use his powers to help solve crimes, while his wife Stephanie tries to create more time by using her new super speed. The two children, Daphne and JJ also struggle to figure out what to do with their new skills.
Cast: Michael Chiklis, Julie Benz, Kay Panabaker, Jimmy Bennett, Autumn Reeser, Romany Malco, Stephen Collins, Josh Stewart, Jason Antoon, Guillermo Díaz, Reggie Lee, Jonna Walsh, Christina Chang, James Earl, Lachlan Buchanan
The Powells must join together to save JJ, who's been kidnapped, courtesy of Mrs. X and forced to solve an enigma that could lead to the permanence of the trilsettum's effects. Meanwhile, Joshua reconnects with Katie and discovers that he's about to become a father, and George's fate hangs in the balance as a prisoner aboard a plane that's quickly spiraling out of control and about to crash.
Stephanie ends up traveling to the future and seeing her family's secret revealed, and the consequences that result. Returning to the present, she tries to prevent the future from occurring. Meanwhile, Jim and George track down the criminal responsible for the death of a cop, and Mrs. X assigns someone to watch the pregnant Katie.
The Powell's lives are in danger when a super-villain with animal-like powers is tasked by Mrs. X to eliminate the family. Meanwhile, good girl Daphne takes a rebellious step by ditching school with boyfriend Chris to attend a Sara Bareilles music video shoot. JJ becomes suspicious of Mr. Litchfield's motives when he's presented with different equations from those of the rest of the academic decathlon team; and Katie makes a shocking discovery about Joshua - aka The Watcher.
The mysterious Mrs. X tasks the sexy - and dangerous - Sophie to cause Jim and George to fall under her spell and make them do whatever she wants them to - which could place Jim's marriage in jeopardy. Meanwhile, Stephanie must decide whether or not to inject a patient with the trilsettum serum and risk turning him into a super in order to retain Dr. King's trust, and Daphne's boyfriend, Chris, begins to have suspicions about the Powell family's abilities.
Jim's feelings of guilt are overwhelming when, during a fight with a thug, he diverts a bullet that accidentally hits a boy - causing life-threatening harm. Meanwhile, Daphne's boyfriend, Chris, steals the trilsettum serum from the Powell house and injects his wheelchair-bound father, Roy, with disastrous results; Joshua proposes to Katie; and JJ's teacher takes unscrupulous steps to get him to join the school's academic decathlon team.
The Powells' lives are in danger when Dr. King orders shape-shifter Victoria Morrow to infiltrate the household and murder one of the family members; and JJ, with the aid of Daphne, attempts to solve the cold case murder of his ex-girlfriend Natalie's mother.
After a friend is attacked, Stephanie tells Jim that she wants to join forces with him to help catch the perp. But when Jim informs Stephanie that he's built for crime fighting - and she's not - the competition is on to see which one of them can solve the case first. Meanwhile, Daphne feels like Jim is invoking a double standard when he allows JJ to date a senior but won't let her do the same, and Katie learns some disturbing news about Joshua, aka The Watcher.
While Internal Affairs officer Rachel Jacobs investigates reports of a rogue cop, Jim risks revealing himself as the prime suspect when the police station is overrun by a group of thugs, and he is the only hope of survival. Meanwhile, while trying to nurse an ailing Joshua back to health at the lab, Katie and Stephanie run into Human Resources VP Victoria Morrow and begin to suspect that she isn't who she says she is.
Jim's wayward brother, Mike, makes a surprise visit to the Powell household and discovers the family has powers. But in an attempt to make some quick cash, he tries to convince JJ to using his abilities to win big by betting on the horses. Meanwhile, in a surprise twist, Katie is given a promotion at Global Tech by Human Resources VP Victoria Morrow, who may be hiding a secret agenda, and Daphne is placed on the school's peer disciplinary committee and believes a student may have been wrongly accused of possessing drugs.
After Jim saves Dave Cotten's life, he and Stephanie become fast friends with Dave, his wife, Michelle and their kids. But Jim begins to suspect that the Cottens may be leading their own secret lives. Meanwhile, Daphne throws her hat into the high school ring for student council president, and Katie reveals a secret to Stephanie about her relationship with Joshua - aka The Watcher.
After George is mistaken as a hero for thwarting a robbery that Jim was responsible for stopping, tempers flare between the two friends when George thinks Jim is jealous of the attention he's receiving, and Jim feels that George is taking credit for something he didn't do and hogging the limelight. Meanwhile, Stephanie and Katie find themselves at odds over personal matters, JJ discovers a weakness in his powers, and Daphne's suspicions over Katie's boyfriend intensify.
Jim and Stephanie plan a romantic evening away from the kids to celebrate their 18th wedding anniversary, but instead find themselves teaming up and using their superpowers to deal with a serial arsonist who is exhibiting some special powers of his own. Meanwhile, Daphne and JJ are left home alone and join forces to win some big money in a poker game with some fellow students.
Stephanie tries to uncover the reason behind Jim's sudden loss of powers, which could put an end to his crime fighting days; JJ may be facing criminal charges after he's caught hacking into the school computer system by his teacher; Daphne uses her abilities to impress a boy; and Katie begins falling for her mysterious new beau.
Jim goes after a mobster who has plagued George for years, ignoring his friend's request to stay out of the case. Meanwhile, Stephanie disobeys Dr. King's wishes and tries to find out more about Volson's research, and Daphne asks JJ to use his powers to help her impress a boy.
Jim's in-laws, Barbara and Allan, arrive for a surprise visit and Stephanie and Jim scurry to keep their powers a secret. However, they soon realize that something is going on. Meanwhile, Jim tries to track down some home invaders while trying to maintain his secret, and wants Daphne to help over Stephanie's objections.
Jim comes across someone else with powers, but isn't using them for the greater good. Meanwhile, Stephanie and Katie pursue the secret of Volson's research, Daphne telepathically learns a startling secret about a classmate, and JJ continues to try and hide his secret.
Jim is mistaken for a vigilante while trying to protect people in the park at night. Meanwhile, Daphne uses her powers to get herself invited to a party she normally wouldn't have been considered for.
Jim and George crash a wedding to catch the thieves who stole Stephanie's wedding ring. Meanwhile, Stephanie is forced to break into a secure lab to retrieve Katie's blood sample after the lab tech substitutes her blood for Stephanie's to protect her, Daphne considers telling a friend about her powers, and JJ asks his sister to read a girl's mind and find out if she likes him.
The Powells keep secrets from each other as JJ hides his new ability from everyone, and Jim and Stephanie secretly break their promises to the other not to use their powers. Meanwhile, Jim takes on bank robbers and Stephanie attempts to determine the source of their powers.
The Powell family must learn to deal with the super powers each has mysteriously acquired after the crash of their plane in the Amazon River. Jim discovers that he has the power of super strength and immediately feels a new sense of purpose and empowerment. Stephanie developing the power of speed, she can now move effortlessly through her daily responsibilities. For 16-year-old Daphne, she turns telepathic and hears other people's hopes, dreams, fears and joys, whether she cares to or not. And 14-year-old JJ finds his mental abilities strengthened to a super genius level.