When Cesare lands in northern Italy with a French army, Alexander is furious at what he sees as a challenge to his authority, but reluctantly accedes to Cesare's plan to destroy the Sforza dynasty. Catherina, meanwhile, has come up with a plot of her own: biological warfare. Concerned about the lack of funds for his Crusade, Alexander imposes punitive taxes on the newly arrived Jewish community.

Cast: Jeremy Irons, François Arnaud, Holliday Grainger, Sean Harris, Thure Lindhardt, Gina McKee, Peter Sullivan, Charlie Carrick, Sebastian De Souza, Edward Hogg, Prometheus Aleifer, Pilou Asbæk, Leo Bill, Brendan Cowell, Cyron Melville