Cesare burns Constanzo's palace in order to contain the plague. Lucrezia, aware that the political wind has changed towards France, seeks a Neapolitan power base for herself and her family. Lucrezia blackmails Prince Raphael and Prince Frederigo replaces Ferdinand as King.

Cast: Jeremy Irons, François Arnaud, Holliday Grainger, Joanne Whalley, Lotte Verbeek, Sean Harris, Thure Lindhardt, Julian Bleach, Peter Sullivan, Charlie Carrick, Sebastian De Souza, Prometheus Aleifer, Luke Allen-Gale, Pilou Asbæk, Leo Bill