Centers on an ultra-competitive surgeon whose life is changed forever when his ex-wife dies and begins teaching him what life is all about from the here-after.
Cast: Patrick Wilson, Jennifer Ehle, Margo Martindale, Pablo Schreiber, Afton Williamson, Armando Riesco, Marin Ireland, Sue Jean Kim
Michael learns that a patient at the clinic has a special connection to Anna. Meanwhile, Michael reunites with an old friend who is suffering from a rare illness.
When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.
When a spoiled pop star comes to Holt Neuro experiencing unusual symptoms, and a young girl at the Clinica exhibits similar symptoms on the same day, it forces both teams of doctors to try and piece together their common link.
A distraught woman takes the Clinica staff hostage after Michael testifies for a former patient who he believed suffered uncontrollable urges due to a brain tumor.
Michael saves a man from drowning and learns his identity is a mystery. Meanwhile, Kate discovers a girl she mentors has serious issues that she has failed to notice.
Michael and E-Mo disagree about how to treat a patient with a brain tumor. Meanwhile, a teenage girl gives birth at the clinic and immediately runs out, leaving the baby behind.
While tending to patients at the clinic during a blizzard, Michael shows signs of a severe condition that requires immediate surgery.
Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.
Rita and her husband (Tom Wopat) want Michael to operate on their son after he gets injured in a motorcycle accident on Thanksgiving. Elsewhere, Kate and Zeke revive a patient who has a DNR order.
When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life...
While at the clinic, Michael runs into a former football star that he performed successful surgery on years ago, and is now a shell of his former self, living on the streets. At Holt Neuro, Michael examines a patient who suffers from post-traumatic stress disorder.
Michael must decide if it is worth risking his practice to save a patient's life. Meanwhile, he courts Evan "E-Mo" Morris, a neuropsychiatrist to join his practice after E-Mo determines a patient's diagnosis by reading her body language.
When Michael treats a patient who is hearing voices, he turns to Anton for help. Meanwhile, Kate's first day at the clinic doesn't go well.
While interviewing doctors to run the clinic, Michael helps a man who passed out, but refuses care due to lack of insurance. Meanwhile, as Michael evaluates a woman, he notices lesions on her brain that require immediate surgery, even as he doesn't know the exact diagnosis.
Waltenate and his team call upon their counterparts from This Side for help when a serial killer goes on a bloody rampage. However, when they recruit the killer's This Side counterpart, a professor of forensic psychology, the team is forced to consider whether they can put civilians at risk.
After the ghost of Michael's ex-wife visits him from the afterlife and asks him to help continue running her low income clinic, he finds himself rushing back and forth between taking care of his own patients at Holt Neuro and her less fortunate patients at the clinic.