When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.

Cast: Patrick Wilson, Jennifer Ehle, Margo Martindale, Pablo Schreiber, Rachelle Lefevre, Rhys Coiro, Julie Benz, Roslyn Ruff, Eriq La Salle, Tijuana Ricks