Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.

Cast: Patrick Wilson, Jennifer Ehle, Margo Martindale, Pablo Schreiber, Rhys Coiro, Rachelle Lefevre, Liam Aiken, Vondie Curtis-Hall, Aaron Dean Eisenberg, Afton Williamson, Mike Doyle, Diane Kagan, Julie Benz, Chris Barnes, Marsha Stephanie Blake