After the death of Ludovico's wife, he is given a new art commission but struggles with inner turmoil. After reflecting on wise words from Father Luca Pacioli, Leonardo seeks assistance from friends and presses on with the work, despite tensions in the city.

Cast: Aidan Turner, Matilda De Angelis, James D'Arcy, Alessandro Sperduti, Carlos Cuevas, Miriam Dalmazio, Giovanni Scifoni, Max Bennett, Claudio Castrogiovanni, Antonio De Matteo, Gabriel Lo Giudice, Josafat Vagni, Freddie Highmore, Anton Alexander, Robert Madison