A woman who moves into an apartment next door to two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
Cast: Johnny Galecki, Jim Parsons, Kaley Cuoco, Simon Helberg, Kunal Nayyar, Carol Ann Susi, Sara Gilbert, Kevin Sussman, Melissa Rauch, Mark Harelik, John Ross Bowie, Brian George, Alice Amter, Sara Rue, Brian Wade
Sheldon and Amy await big news. Bernadette and Wolowitz leave their kids for the first time; Penny and Leonard try to keep a secret.Koothrappali makes a new friend; the gang travels together into an uncharted future.
Leonard is pleasantly surprised when Beverly comes to visit and she's genuinely kind to him, until he finds out the real reason she's there. Also, Denise and Stuart overstay their welcome at the Wolowitz house.
Kripke has proof that Dr. Pemberton plagiarized his thesis in college, and Sheldon and Amy aren't sure if they should turn him in or not. Also, Wolowitz is happily surprised to learn that Bernadette wasn't the only waitress at the Cheesecake Factory who had a crush on him back in the day.
Koothrappali is worried people won't take him seriously in his own field after publishing a paper that suggests he may have discovered alien life; Leonard wants to be the principal investigator on a plasma physics study.
The concept of what it would mean for women everywhere if Amy were to win a Nobel Prize causes Amy to have a meltdown. Also, Koothrappali and Wolowitz try to relive the good old days after Wolowitz buys a scooter that looks like the one he had years ago.
When competitors Pemberton and Campbell charm America on a publicity tour, Sheldon and Amy try to win over Nobel laureates Kip Thorne, George Smoot and Frances Arnold; Halley's fear of the dark leads to opportunity and conflict.
Wolowitz is in charge of the kids while Bernadette and Penny are in San Diego for a pharmaceutical sales convention; Amy and the guys experiment on the kids when Sheldon finds a book on it.
The gang finds out Wil Wheaton hosts a celebrity Dungeons and Dragons game involving William Shatner, Joe Manganiello, Kareem Abdul-Jabbar and Kevin Smith. Deception and betrayal are the path to make it to the one open seat.
Penny tries to throw a wrench into Leonard's plan to be a sperm donor for her ex-boyfriend; Wolowitz, Bernadette, Anu and Koothrappali turn Koothrappali's canceled bachelor party into a couple's trip aboard the "vomit comet."
Sheldon is thrilled to help Bernadette and Wolowitz navigate bureaucratic paperwork, until he discovers they are breaking the law. Also, Leonard is disappointed when his friends exclude him from a scientific project.
Sheldon and Amy's super asymmetry theory is proven by two physicists, Dr. Pemberton and Dr. Campbell from Chicago, who then try to kick Amy off the Nobel nomination. Also, Bernadette has a big success at work and Penny's going to be a part of it—whether she wants to or not.
Penny's ex-boyfriend Zack learns that he is infertile, so he asks Leonard for help; Koothrappali attempts to mend things with his ex-fiancee Anu.
Penny and Leonard organize a paintball game, which results in mayhem when Sheldon becomes jealous of Amy. Raj catches Anu with her ex-boyfriend. Stuart doesn't want to move in with Denise.
A VHS tape from Sheldon's past inspires him and Amy not to give up when they're still feeling down about their theory being disproven.
Sheldon and Amy are devastated after learning from a Russian paper that Super Asymmetry has already been discovered and disproven. Also, ultra-competitive Bernadette asks Stuart's girlfriend, Denise, to teach her how to beat Howard in a popular videogame.
Sheldon tries to bond with Amy's father, but when Wolowitz lures Mr. Fowler away with magic tricks, Sheldon has no choice but to bond with Mrs. Fowler. Also: Koothrappali and Anu try to get physical for the first time.
Leonard is caught between a rock and a hard place when he's responsible for distributing extra grant money. Also, Bernadette turns the backyard playhouse into a hideaway from her husband and kids.
When Wolowitz dresses up as Sheldon for Halloween, Sheldon seeks retaliation at Leonard and Penny's Halloween party. Also, Leonard is shocked that Penny doesn't remember their first kiss.
Amy doesn't have time to work on super-asymmetry, so Sheldon goes to great lengths to ensure she's available to work with him even it if means accidentally sabotaging her career in the process. Also, Koothrappali doesn't want Wolowitz to join him in hosting a show at the planetarium.
Sheldon won't tell anyone why he's never mentioned Tam, his childhood best friend, so Leonard takes matters into his own hands. Also, Bernadette and Penny take out Raj's fiancée, Anu, for dinner to get the skinny on her.
The Wolowitzes' life gets complicated when Stuart starts bringing his new girlfriend home. Also, Penny and Leonard talk about starting a family while Koothrappali explores an arranged marriage.
Leonard and Penny give Sheldon and Amy a baffling wedding gift.
After their wedding, Amy and Sheldon go on their honeymoon.