Explorer Sir Malcolm Murray, American gunslinger Ethan Chandler, scientist Victor Frankenstein and medium Vanessa Ives unite to combat supernatural threats in Victorian London.
Cast: Reeve Carney, Timothy Dalton, Eva Green, Rory Kinnear, Billie Piper, Harry Treadaway, Josh Hartnett, Danny Sapani, Simon Russell Beale, Douglas Hodge, Sarah Greene, Helen McCrory, Jack Hickey
Sir Malcolm and his allies battle the fiend laying claim to Vanessa, the Creature faces a baleful demand, and Ethan makes a heartrending choice.
Ethan, Sir Malcolm and Kaetenay return to London, where Ethan searches for Dr. Frankenstein. Meanwhile, Dr. Seward discovers Renfield's secret; and Lily reveals a heartbreaking story from Brona Croft's past.
Kaetenay has a vision of impending doom; Frankenstein and Jekyll get help from an unlikely foe; the Creature finally gains courage; Vanessa learns an awful truth.
Vanessa turns to old friend Ferdinand Lyle for help, who introduces her to Catriona Hartdegen, a new ally. Meanwhile, Lily, Dorian and Justine put their plan in motion; and Ethan, Sir Malcolm and Hecate arrive at Jarod Talbot's ranch.
Hecate and Ethan struggle to survive in the harsh desert wasteland.
With the help of Dr. Seward, Vanessa undergoes hypnosis to relive her time in the Banning Clinic.
Miss. Ives is confronted by a familiar who will reveal a clue to Vanessa's past.
Lily and Dorian, rescue a young woman. Sir Malcolm continues on his journey with the enigmatic Kaetenay. Meanwhile, Ethan gets some unexpected help from Hecate. Dr. Frankenstein and Dr. Jekyll hatch a plan. Vanessa's relationship with Dr. Sweet grows but, unbeknownst to her, evil forces are tracking her every move.
In the season 3 premiere of Penny Dreadful; Ethan is a prisoner under Inspector Rusk's watch heading through America. Sir Malcolm meets a mysterious native american while in Africa. Frankenstein gets a visit from an old friend: Dr. Jekyl. Vanessa seeks the help of a very intriguing and interesting doctor.