In the season 3 premiere of Penny Dreadful; Ethan is a prisoner under Inspector Rusk's watch heading through America. Sir Malcolm meets a mysterious native american while in Africa. Frankenstein gets a visit from an old friend: Dr. Jekyl. Vanessa seeks the help of a very intriguing and interesting doctor.

Cast: Reeve Carney, Timothy Dalton, Eva Green, Rory Kinnear, Patti LuPone, Billie Piper, Wes Studi, Harry Treadaway, Josh Hartnett, Christian Camargo, Douglas Hodge, Simon Russell Beale, Shazad Latif, Sarah Greene, Samuel Barnett