When a twenty-something computer geek inadvertently downloads critical government secrets into his brain, CIA and NSA assign two agents to protect him and exploit such knowledge, turning his life upside down.
Cast: Zachary Levi, Yvonne Strahovski, Sarah Lancaster, Adam Baldwin, Vik Sahay, Scott Krinsky, Joshua Gomez, Ryan McPartlin, Mark Christopher Lawrence, Bonita Friedericy, Julia Ling, Tony Hale, Brandon Routh, Tony Todd, Jesse Heiman
Chuck enlists the help of his family, friends, and even the employees of the Buy More to stop Nicholas Quinn from destroying everything they have.
Sarah keeps an important secret from Chuck in order to insure the success of a mission. Ellie and Awesome receive some life-changing news.
When a mission in Japan becomes a hostage situation, Sarah and Chuck must face the merciless Nicholas Quinn (guest star Angus Macfadyen) aboard a speeding Japanese bullet train. Meanwhile, the mission leaves Casey with an impossible decision.
Morgan's time with the Intersect compels Chuck and Sarah to take on a mission in Vail and enlist the help of a famous actress. Jeff and Lester continue their own spy mission.
While Chuck and Sarah contemplate the next step for Carmichael Industries, Casey's forbidden love, Gertrude Verbanski (guest star Carrie-Anne Moss), walks back into his life with a questionable mission in South Beach. Meanwhile, Jeff's enhanced intelligence leads he and Lester to suspect that something unusual may be happening at the Buy More.
When Sarah's old spy handler reappears, she goes off on her own to prevent a secret from her past from destroying her family.
Chuck and Sarah discover who is behind a plot to take down their company. A computer virus creates havoc as the Buy More prepares for Christmas. Ellie tries to make Christmas plans for everybody.
Chuck and Sarah race against time to take down a dangerous computer virus, pitting them against Robyn Cunnings (guest star Rebecca Romijn), a ruthless spy who will stop at nothing to get what she needs. Meanwhile, Ellie and Awesome's date night takes a dangerous turn and Morgan is sent on a special mission to recover Chuck's P.A.N.T.S.
Chuck and Sarah infiltrate an unusual cult to find the designer of a computer virus. The Buy More gets a new employee.
Mystery deepens at a Buy More sales convention when Chuck and Sarah must unmask an assassin lurking among the conventioneers. Meanwhile, Intersect complications affect Morgan; and Jeff shows there's more to him than just being a "Buy Moron." David Koechner and Catherine Dent guest star
Chuck worries Morgan is letting the Intersect change his attitude for the worse. Sarah gives Casey relationship advice on Gertrude Verbanski. Captain Awesome discovers shocking news about Jeff and Lester.
As Carmichael Industries takes on a missing persons case, Chuck must acclimatize himself to being Morgan's handler and deal with a rival agency. The Buy More gets a new spokesperson.
Now the head of his own spy agency, Chuck takes on a slick thief and an investor who has stolen money from dangerous criminals. Morgan aids Chuck in planning a surprise for Sarah. Jeff and Lester launch their latest scheme at the Buy More.