Thackery enlists Edwards to help him test a new hypothesis. After rejecting Robertson’s advances at The Knick, Lucy learns that confession isn’t always good for the soul. Young journalist Genevieve Everidge works on a story about one of Thackery’s rivals. Cornelia is dismayed by the limits of her husband’s sympathies. Barrow faces a new adversary at Tammany Hall. Gallinger is intrigued by a discussion of eugenics at a class reunion. Edwards deals with a surprise visitor.

Cast: Clive Owen, André Holland, Jeremy Bobb, Juliet Rylance, Eve Hewson, Michael Angarano, Chris Sullivan, Cara Seymour, Eric Johnson, Maya Kazan, Leon Addison Brown, Zaraah Abrahams, Charles Aitken, LaTonya Borsay, Rachel Korine