Peter volunteers as photographer for an old Pullitzer winner discarded by Jonah. The discover the underworld's recently release former kingpin Sable Manfredi is auctioning genetic technology to create monsters at will. As Spiderman, he tries to keep it out of the bid-winner's hands, but soon finds that also means taking on sore losers.

Cast: Josh Keaton, Clancy Brown, Lacey Chabert, Nikki Cox, Grey DeLisle, John DiMaggio, Tricia Helfer, Andrew Kishino, Peter MacNicol, Daran Norris, Alan Rachins, James Arnold Taylor, Alanna Ubach, Courtney B. Vance, Greg Weisman