Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient's family. Jo and Link struggle with wedding planning.

Cast: Ellen Pompeo, Chandra Wilson, James Pickens Jr., Kevin McKidd, Caterina Scorsone, Camilla Luddington, Kim Raver, Jason George, Chris Carmack, Anthony Hill, Adelaide Kane, Alexis Floyd