An astronaut (Halle Berry) returns home from a year long solo mission in space. She tries to reconnect with her husband and son in their everyday life. Her experiences in space and home lead to events that ultimately will change the course of human history.
Cast: Brad Beyer, Halle Berry, Goran Visnjic, Pierce Gagnon, Camryn Manheim, Tyler Hilton, Sergio Harford, Grace Gummer, Michael O'Neill, Jeannetta Arnette, Annie Wersching, Shree Crooks, Eme Ikwuakor, Maury Sterling, Owain Yeoman, Hiroyuki Sanada, Tami Roman, Alisha Boe, Gabrielle Conforti, Sam Golzari, Louis Gossett Jr., Jimmy Jean-Louis, Anzu Lawson, Raymond Mamrak, Nicolas Pajon, Doug Simpson, Shana Vonn
Molly and JD frantically race to the hybrids to stop a Humanich plot that will destroy the human race. Also, Lucy has a shocking realization about the GSC that forces her to question her allegiance and put Ethan at risk.
Molly reveals disturbing new details about Shepherd's death to the GSC, and Lucy makes a powerful move against the humans and hybrids that could have devastating global repercussions.
Molly manages to find John's former colleague with JD and Ethan hoping to be able to stop the Humanich threat. Julie sends Charlie on a mission to discover where Lucy's orders are coming from.
Molly has a vision she can't stop thinking about after a near-death experience. Shepherd's loyalty to the Global Space Commission is tested.
Memories cone to the surface as Molly gets the virus. Julie has to make some hard choices.
After a Global Security Commission raid on the hybrid compound, Molly desperately tries to save her son, Adhu; meanwhile JD attempts to rescue his daughter, who is being held captive by Shepherd. Meanwhile, Lucy becomes more of a threat to humans.
Molly and JD want peace and they attempt to get Shepherd to agree to a deal between humans and hybrids. Lucy attempts to manipulate Charlie's feelings to leave him in a compromising position
Molly panics when she discovers she is changing physically - the question is into what, and whether she can reverse what's happening to her. Also, JD's ex-wife, Dorothy, shows up suddenly on his doorstep to discuss their daughter.
Molly realizes that Ethan is still alive and attempt to get him back. JD looks into John's death, after suspicions arise about Julie's possible involvement.
Molly tries creating a virus to destroy alien hybrids and discovers that aliens are trying to communicate with humans through a hidden message in their DNA. Elsewhere, Lucy helps Ethan run away from Charlie to help him recover memories of Molly.
Molly finally learns the frightening truth about what happened to her son. Also, Julie's decision to erase Ethan's memory has disturbing consequences.
Molly and JD discover another pregnant woman who is suffering with the same unexplainable and deadly symptoms.
Molly escapes from a psychiatric hospital and investigates some deaths that seem strangely familiar.