Due to a political conspiracy an innocent man is sent to death row and his only hope is his brother who makes it his mission to deliberately get himself sent to the same prison in order to break the both of them out from the inside out.
Cast: Dominic Purcell, Wentworth Miller, Amaury Nolasco, Robert Knepper, Sarah Wayne Callies, Wade Williams, William Fichtner, Paul Adelstein, Silas Weir Mitchell, Marshall Allman, Rockmond Dunbar, Jodi Lyn O'Keefe
Dangerous threats keep Michael and Lincoln fighting to protect Sara and Mike in the Season 5 finale. Meanwhile, Poseidon continues to try and outsmart Michael and the rest of the gang, which leads them to the ultimate showdown—and not everyone makes it out alive.
Michael and Lincoln enlist the help of Sheba and C-Note to catch Poseidon when Sara and her son are threatened; Whip takes a separate mission; T-Bag reveals a secret.
Sara fears for her family's safety when she discovers the reason why Michael faked his death; Sucre helps Michael and Lincoln find a way home; Poseidon's true identity is revealed.
Michael, Lincoln and the Ogygia gang race through the desert pursued by Cyclops; A&W and Van Gogh question their roles when their trailing the escapees leads them to Graceland.
Lincoln becomes frustrated as he tries to understand what really happened to Michael. Meanwhile, C-Note has a new escape plan, but fears it will not be executed quickly enough as Cyclops is trailing closely behind; at the same time, Sara struggles with the idea that Michael may be alive.
Michael, Whip and Ja make their last attempt to break from Ogygia, but must make a deal with the devil to do so. Lincoln races against the clock to help with the escape, as T-Bag meets with Kellerman to gather more info on Michael's resurrection.
When T-Bag ambushes Sara, he warns her that two of Poseidon's henchmen, Van Gogh and A&W, may be following her. Meanwhile, Lincoln attempts to retrieve his confiscated passport to escape Yemen, and Michael plans his next move.
As Lincoln and C-Note search for the "Sheik of Light," Michael and his cellmate, Whip, attempt an escape from Ogygia. Meanwhile, Sara's investigation into Michael's reappearance leads her to the state department and an uneasy reunion with Paul Kellerman.
Seven years has passed and with everyone moved on with their lives, Michael is discovered to still be alive after his apparent death and has ended up in a Yemen prison. Lincoln gets a visit from a familiar face and learns the news about Michael and his whereabouts.