A group of doctors from the Army return to work the night shift at a hospital in San Antonio.
Cast: Eoin Macken, Jill Flint, Ken Leung, Brendan Fehr, Robert Bailey Jr., JR Lemon, Scott Wolf, Jeananne Goossen, Freddy RodrÃguez, Esodie Geiger, Alma Sisneros, Catharine Pilafas, Merle Dandridge
A shooting at a nearby college sends TC, Jordan, Drew and Amira into the field, where they assist Rick with a deadly situation. Scott implements a new training program and locks horns with Julian. Drew struggles with frustrations about going to Army Ranger School while Shannon and TC both contemplate their future at San Antonio Memorial.
TC and Jordan accompany a SWAT team on a raid and wind up with an emergency room full of sickened immigrants, including one with murderous intentions; and Scott pulls a dream team together to impress the Colonel in charge of setting up a combat training program.
A cyber attack creates chaos in the hospital. Meanwhile, Drew draws on his medical and military training to treat a critical patient, and TC joins on a SWAT drug raid. Also: TC contemplates returning to Syria to tie up loose ends.
Multiple veterans are injured and brought to the hospital. Also, a politician from Drew's past triggers flashbacks to his time in Iraq; Paul and Shannon must improvise while tending to a former POW; and a fearless photographer is treated.
Kenny joins Drew at his MMA veteran's support group and finds himself in the fight of his life. Jordan and Cain treat casualties from a hotel fire while Shannon follows a hunch to help save a young victim. Paul's superstar sister, Dr. Bella Cummings, pays a visit to San Antonio Memorial and provides desperately needed support during a busy shift.
Drew faces an emergency on his flight home when passengers become sickened. Also, some staffers participate in an obstacle-course fund-raiser hosted by Akbar Gbajabiamila ("American Ninja Warrior"); Scott has an unforgettable date; TC treats a soldier.
A patient from a distant town arrives for surgery. Meanwhile, Jordan gets creative to help a veteran in need; Drew struggles with being a working parent; Kenny learns to not worry about trivial matters; and TC joins in a daring rescue mission in Syria.
Jordan and Cain figure out their professional dynamic; Drew and Paul must find a way to save a patient's severed hand; Annie shows up to the hospital with an unexpected guest from Scott's past; TC and Amira treat a Syrian child on the base.
Drew is forced to re-evaluate his priorities as a new father; the ER is flooded with mass casualty victims from an amusement park disaster; Jordan helps appease Paul and his father; Scott pursues a more active role in the hospital.
Jordan and Drew perform a daring rescue by jumping from a chopper; Paul deals with the repercussions of standing up to his father; Shannon indoctrinates Cain; TC must treat his captor to rescue Syd.