Tully and Kate support each other through good times and bad with an unbreakable bond that carries them from their teens to their forties.
Cast: Katherine Heigl, Sarah Chalke, Ben Lawson, Ali Skovbye, Roan Curtis, Yael Yurman, Jon-Michael Ecker, Beau Garrett, Brendan Taylor, Chelah Horsdal, Brandon Jay McLaren, Quinn Lord, Paul McGillion, Synto D. Misati, Jenna Rosenow, Kirsten Robek
On a special day for the Mularkey family, Tully reflects on decades of work, love, grief, and joy alongside her best friend. Kate faces the unknown.
Tully, Johnny, and Marah try to find ways of coping after Kate's revelation. In the 1980's, Johnny wrestles with another piece of overwhelming news.
Kate and Johnny's loved ones gather together for two very different celebrations. Tully gets tangled in a romantic dilemma and Kate feels the weight of a secret.
A bridal shower stirs up resentments and memories, an awkward encounter leads to a life changing question, and a tragedy shakes teenage Kates life.
Johnny and Kate reminisce at a party about a life changing kiss in the same newsroom, 20 years earlier. Tully gives Danny advice on his love life.
From bra stuffing to breastfeeding, Kate experiences several bumps in the road on her journey from a self conscious teen to a first time mom.
Kate has often felt invisible next to Tully through the years but amid major changes, Kate realizes she may need her best friend by her side.
For the first time in decades, Kate and Tully experience a year apart — but can they handle major life events without each other?
Kate learns that dealing with an ex is always tricky, no matter the decade. After years of never saying sorry, Tully struggles with accountability.
Tully attempts to face unresolved loose ends from her past. But her choices lead to a potentially unforgivable mistake that impacts Kate's life.
While celebrating their own freedom on Independence Day, Tully and Kate learn time and again that relying on each other may not be so bad after all.
From a double date in 1975 to Tully's search for her father in 2004, Tully and Kate attempt to take charge of their futures — but fate has other plans.
As Tully's career takes off, uncomfortable encounters at work keep throwing her off track. Johnny's behavior causes concern among his loved ones.
A teen magazine. A political investigation. A secret message. Shocking revelations lead to major questions for Sean, Tully and Kate.
Over the decades and several road trips, Tully and Kate strengthen their bond and forge new relationships while occasionally testing them.
Trying times bring Kate and Tully together as they contend with an overbearing grandma, a pesky new intern and an ex-husband in distress.