Two Angels, Panty and Stocking, are kicked out of Heaven for bad behaviour and sent Ghost hunting by Garterbelt, a Priest of Daten City.
Cast: Jamie Marchi, Arisa Ogasawara, Mariya Ise, Kôji Ishii, Monica Rial, Christopher Sabat, Takashi Nakamura, Ian Sinclair, Terri Doty, Joel McDonald, Hiroyuki Yoshino, Miki Makiguchi, Yuka Komatsu, Ayumi Fujimura, Christopher Bevins, Koichi Bando, Colleen Clinkenbeard, Cherami Leigh
Panty settles into a normal quiet life on a farm, but an attack enrages her into becoming the hardcore angel she once was.
Stocking gets to go to Heaven, but Panty is left behind on Earth. To make matters worse, her powers start to fade away and Briefs is kidnapped.
Panty and Stocking learn of Garterbelt's past. Later, they spend a whole day in a room lazing around.
Panty and Stocking are sent inside Brief's body, and later perform a concert. Meanwhile we take a look at Chuck's life.
The Angel and Demon sisters face off at the beach. Later, Stocking falls in love with a ghost.
Panty and Stocking are trapped in a town filled with zombies. Later, they are put on trial for killing an innocent ghost.
Panty and Stocking get caught up in a robot war. Later, they must find a way to earn money.
Panty and Stocking meet their demonic counterparts, the Sisters of Order Scanty and Kneesocks.
An ecstatic nose-picking fad spreads across Daten City. Later, a struggling worker can't go home for his daughter's birthday and makes a ghost made of vomit.
Stocking finds herself gaining weight because of a ghost and goes on an intense diet. Later, a race is hampered by an underwear-eating ghost.
Panty and Stocking start a fight which sends a Ghost-hunting mission awry. Later, the phantoms of angry sperm take cause a shortage of tissue paper.
Panty and Stocking go undercover at a school to investigate disappearances. Later, a porn film starring Panty appears and the girls go to great lengths to recover all its copies.
Panty and Stocking are sent to investigate cases of people being eaten by toilets. Later, they chase down a ghost who can possess vehicles.