Two university students come across a seemingly harmless girl named Lucy, unaware that she's actually a mutant serial killer with a split personality.
Cast: Sanae Kobayashi, Chihiro Suzuki, Mamiko Noto, Sam Saletta, Kira Vincent-Davis, Cynthia Martinez, Nancy Novotny, Adam Conlon, Emiko Hagiwara, Yuki Matsuoka, Hitomi Nabatame, Osamu Hosoi, Masakazu Kohara, Jôji Nakata, Kinryû Arimoto, Maria Yamamoto, Eriko Ishihara, Ken Takeuchi
Nana almost falls into the ocean, but Kurama arrives to save her. Kurama tells Nana that he must kill Mariko and they go search for her.
Mariko enjoys playing around with Nana since she is only allowed to kill her. Kohta arrives at the scene and Nana saves him by falling into the ocean
Kurama leaves the facility to talk to Bandoh; they make a deal that involves the destruction of Mariko.
Kurama remembers his past. After graduating college, professor Kakuzawa offers him a chance at top secret research. While at the offshore facility, Kurama witnesses first-hand the terror of the diclonius.
Still in her fever dream, Lucy remembers more of her past. By chance she met Kohta, the first human being to treat her with compassion and truly be her friend.
After being briefly attacked by Nana, Nyu reverts to Lucy and catches a fever. While Nana tries to convince Mayu that she's dangerous, Lucy remembers her past as an orphan who was constantly bullied.
Nana returns to Kamakura after Kurama disobeys orders to kill her. While there, she runs into Mayu and soon becomes friends with her.
Kurama asks Nana to find Lucy with her powers of Diclonius. Yuka realizes Kohta does not remember his father died in a car accident or that they went to a festival together as small children. Nana finds Lucy.
Kota and Yuka get custody of Mayu and start school. While at the University, a strange professor recognizes Nyu and, pretending to be her uncle, forces Yuka and Kota to give her up.
Nana gets into a deadly fight with Lucy after tracking her down. Meanwhile, Kota suffers a diminishing relationship with Yuka, who has become jealous of Nyu. Yuka discovers that Mayu is homeless.
Kohta takes Nyu in with him while Yuka decides to move in with them. Yuka reminds Kohta of a festival he forgot about, which he remembers ended in a vague tragedy. Meanwhile, the offshore facility sends a friendly Diclonius named "Nana" to find Lucy.
Regretting his angry outburst, Kota sets out to find Nyu and bring her back. Meanwhile, the ruthless mercenary Bando searches for Lucy with orders to kill her (and any witnesses) on sight.
After escaping from her prison in a bloody rampage, murderous diclonious Lucy is shot in the head. She survives, but suffers brain damage, causing her to become harmless and baby-ish. Two university students find her and decide to take care of her, naming her "Nyu".