Michael's life seemed to be perfect, until his long time partner blindsided him after 17 years of being in long time relationship. He has to confront the nightmares of losing his soulmate and suddenly finding himself as a single gay man in his mid-40s.
Cast: Neil Patrick Harris, Tisha Campbell, Brooks Ashmanskas, Emerson Brooks, Marcia Gay Harden, Tuc Watkins, Nic Rouleau, Jasai Chase Owens, André De Shields, Colin Hanlon, Byron Jennings, Jai Rodriguez, Stephanie Faracy, Cynthia Darlow, David Pittu, Jonah Platt, Gonzalo Aburto de la Fuente, April Ortiz
Michael prepares to face his ex at the Jonathans' wedding, where he hopes to negotiate a buy-out on Colin's share of the apartment; Suzanne adjusts to her son having identified his birth father; Stanley receives a sobering diagnosis from his doctor.
During a ski weekend with Billy and Stanley, Michael spirals after receiving an update on Colin's love life; Claire and Suzanne spend a night on the town, during which Suzanne gets some shocking news about her son.
Michael dates a schoolteacher who gets too serious too fast; Claire zeros in on an apartment too close for Michael's comfort; Stanley goes on a date with a fellow art devotee.
Michael comes to grips with his anger and resentment at having to return to a single man's lifestyle; Michael's father sets him up with his dermatologist; Suzanne has an epiphany that explains why she's single.
Michael and Suzanne convince Claire to reinvent herself by finding the right apartment; Michael and Stanley have a falling out; Michael has his first run-in with Colin since the separation; Michael comes to a harsh realization about his role in his relationship's failure.
Billy and Stanley acclimate Michael to new-century dating norms; Suzanne and Michael court the business of an Italian client, which brings unexpected results.
A still shell-shocked Michael hears bits and pieces of Colin's new life through the realtor grapevine; Michael discloses the collapse of his relationship to Claire in an effort to snare her apartment listing from Tyler.
Michael plans an elaborate surprise party for Colin's milestone birthday, but the night takes a devastating turn after a shocking revelation.